(Albany, USA) DelveInsight’s, “PD-1 Non-Small Cell Lung Cancer Pipeline Insights, 2024” report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in the PD-1 Non-Small Cell Lung Cancer pipeline landscape. It covers the PD-1 Non-Small Cell Lung Cancer pipeline drug profiles, including PD-1 Non-Small Cell Lung Cancer clinical trials and nonclinical stage products. It also covers the PD-1 Non-Small Cell Lung Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key takeaways from the PD-1 Non-Small Cell Lung Cancer Pipeline Report
- Over 30+ PD-1 Non-Small Cell Lung cancer companies are evaluating 30+ PD-1 Non-Small Cell Lung Cancer pipeline therapies in various stages of development, and their anticipated acceptance in the PD-1 Non-Small Cell Lung Cancer market would significantly increase market revenue.
- The leading PD-1 Non-Small Cell Lung Cancer Companies include Novartis, AstraZeneca, Eli Lilly and Company, Pfizer Inc., F. Hoffmann-La Roche Ltd., Merck, Bristol Myers Squibb, Sanofi, IO Biotech, Daiichi Sankyo, Inc., Regeneron Pharmaceuticals, and others.
- Promising PD-1 Non-Small Cell Lung Cancer Pipeline Therapies includes REGN2810, Chemotherapy, CV301, Pembrolizumab, Nivolumab, Cyclophosphamide, DV281, Breath Actuated Nebulizer, DV281 (RP2D), AK105, carboplatin, pemetrexed, Tislelizumab, Docetaxel, TSR-042 (Dostarlimab), MK-3475, and others.
- The PD-1 Non-Small Cell Lung Cancer companies and academics are working to assess challenges and seek opportunities that could influence PD-1 Non-Small Cell Lung Cancer R&D. The PD-1 Non-Small Cell Lung Cancer pipeline therapies under development are focused on novel approaches to treat/improve PD-1 Non-Small Cell Lung Cancer.
To explore more information on the latest breakthroughs in the PD-1 Non-Small Cell Lung Cancer Pipeline treatment landscape of the report, click here @ PD-1 Non-Small Cell Lung Cancer Treatment Market
PD-1 Non-Small Cell Lung Cancer Overview
Programmed death-1 (PD-1) inhibitors represent a groundbreaking advancement in the treatment of non-small cell lung cancer (NSCLC), the most prevalent form of lung cancer. PD-1 is a checkpoint protein on immune cells that, when engaged by its ligands PD-L1 or PD-L2, suppresses immune responses. Many tumors, including NSCLC, exploit this pathway to evade immune detection and destruction.
PD-1 inhibitors, such as pembrolizumab (Keytruda) and nivolumab (Opdivo), block this interaction, thereby reactivating the immune system to recognize and attack cancer cells. These drugs have significantly improved outcomes for patients with advanced or metastatic NSCLC, particularly those whose tumors express high levels of PD-L1.
Clinical trials have demonstrated that PD-1 inhibitors can lead to durable responses and prolonged survival in a subset of patients, with some achieving long-term remission. They are often used as monotherapy or in combination with other treatments, such as chemotherapy or targeted therapies, depending on the specific characteristics of the cancer and patient.
Despite their efficacy, PD-1 inhibitors can cause immune-related adverse effects, ranging from mild to severe, and necessitating careful management. Ongoing research aims to enhance the efficacy of PD-1 inhibitors, identify biomarkers for better patient selection, and develop combination strategies to overcome resistance, further improving outcomes for NSCLC patients.
Latest Developmental Activities or News of PD-1 Non-Small Cell Lung Cancer Treatment Landscape
- In February 2021, Arcus Biosciences initiated a Randomized Phase III Open-label Study will Evaluate the Efficacy of Zimberelimab (AB122) Monotherapy Compared to Standard Chemotherapy or Zimberelimab Combined withAB154 in Front-Line, PD-L1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer.
- Gilead and Arcus entered into a 10-year collaboration that provided Gilead immediate rights to zimberelimab and the right to opt into all other Arcus programs arising during the collaboration term.
For further information, refer to the detailed PD-1 Non-Small Cell Lung Cancer Unmet Needs, PD-1 Non-Small Cell Lung Cancer Market Drivers, and PD-1 Non-Small Cell Lung Cancer Market Barriers, click here @ PD-1 Non-Small Cell Lung Cancer Market Dynamics
Emerging PD-1 Non-Small Cell Lung Cancer Drugs Profile
- REGN2810 (cemiplimab) plus Ipilimumab Combination Therapy (REGN2810/ipi): Regeneron Pharmaceuticals / Sanofi
REGN2810 (SAR439684) is an antibody-based cancer therapy that Regeneron Pharmaceuticals is developing in collaboration with Sanofi. REGN2810 is a monoclonal antibody, or manmade copy of a protein that immune cells generate to fight invaders. It targets a protein called programmed cell death 1, or PD-1, on the surface of immune T-cells and precursor B-cells, or pro-B cells. Precursor B-cells are immature white blood cells that develop into fully formed B-cells. PD-1 suppresses the immune system by binding to programmed death-ligand 1, or PD-L1 — another cell surface protein that several cancers overproduce. By binding with PD-1, REGN 2810 blocks the interaction between PD-1 and PD-L1, promoting T-cell growth and survival. The result is a revved-up immune system that can then attack cancer cells.
- Tislelizumab (BGB-A317) – BeiGene
Tislelizumab (BGB-A317) is a humanized IgG4 anti–PD-1 monoclonal antibody specifically designed to minimize binding to FcγR on macrophages. In pre-clinical studies, binding to FcγR on macrophages has been shown to compromise the anti-tumor activity of PD-1 antibodies through activation of antibody-dependent macrophage-mediated killing of T effector cells. Tislelizumab is the first drug from BeiGene’s immuno-oncology biologics program and is being developed as a monotherapy and in combination with other therapies for the treatment of a broad array of both solid tumor and hematologic cancers.
PD-1 Non-Small Cell Lung Cancer Pipeline Therapeutics Assessment
There are approx. 30+ key companies which are developing the therapies for PD-1 Non-Small Cell Lung Cancer. The companies which have their PD-1 Non-Small Cell Lung Cancer drug candidates in the advanced stage, i.e. pre-registration and phase III include, BeiGene, Regeneron Pharmaceuticals, Sanofi etc.
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Scope of the PD-1 Non-Small Cell Lung Cancer Pipeline Report
- Coverage- Global
- PD-1 Non-Small Cell Lung Cancer Companies- Novartis, AstraZeneca, Eli Lilly and Company, Pfizer Inc., F. Hoffmann-La Roche Ltd., Merck, Bristol Myers Squibb, Sanofi, IO Biotech, Daiichi Sankyo, Inc., Regeneron Pharmaceuticals, and others.
- PD-1 Non-Small Cell Lung Cancer Pipeline Therapies- REGN2810, Chemotherapy, CV301, Pembrolizumab, Nivolumab, Cyclophosphamide, DV281, Breath Actuated Nebulizer, DV281 (RP2D), AK105, carboplatin, pemetrexed, Tislelizumab, Docetaxel, TSR-042 (Dostarlimab), MK-3475, and others.
- PD-1 Non-Small Cell Lung Cancer Pipeline Segmentation: Phases, Mechanism of Action, Route of Administration, Product Type
Dive deep into rich insights for drugs for PD-1 Non-Small Cell Lung Cancer Market Drivers and PD-1 Non-Small Cell Lung Cancer Market Barriers, click here @ PD-1 Non-Small Cell Lung Cancer Clinical Trials and FDA Approvals
Table of Content
- Introduction
- Executive Summary
- PD-1 Non-Small Cell Lung Cancer: Overview
- PD-1 Non-Small Cell Lung Cancer Pipeline Therapeutics
- PD-1 Non-Small Cell Lung Cancer Therapeutic Assessment
- PD-1 Non-Small Cell Lung Cancer – DelveInsight’s Analytical Perspective
- In-depth Commercial Assessment
- PD-1 Non-Small Cell Lung Cancer Collaboration Deals
- Late Stage Products (Pre-registration)
- Tislelizumab: BeiGene
- Drug profiles in the detailed report…..
- Late Stage Products (Phase III)
- REGN2810/ipi: Regeneron Pharmaceuticals / Sanofi
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- RG 7769: Roche
- Early Stage Products (Phase I)
- TQ B2450: Apollomics; Chia Tai Tianqing Pharmaceutical Group
- Drug profiles in the detailed report…..
- PD-1 Non-Small Cell Lung Cancer Pre-clinical and Discovery Stage Products
- Drug profiles in the detailed report…..
- Inactive PD-1 Non-Small Cell Lung Cancer Products
- PD-1 Non-Small Cell Lung Cancer Companies
- PD-1 Non-Small Cell Lung Cancer Key Products
- PD-1 Non-Small Cell Lung Cancer- Unmet Needs
- PD-1 Non-Small Cell Lung Cancer- Market Drivers and Barriers
- PD-1 Non-Small Cell Lung Cancer- Future Perspectives and Conclusion
- PD-1 Non-Small Cell Lung Cancer Analyst Views
- PD-1 Non-Small Cell Lung Cancer Key Companies
- Appendix
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