New York, USA – May 16, 2024 – CAR-T therapy pioneers the way cancer treatments proceed, which has revealed distinctively promising results in clinical trials. Creative Biolabs has a team of senior scientists specializing in immunotherapy and gene editing subjects, offering one-stop solutions for all CAR-T therapy development needs, from cell engineering to in vivo assays.
“Our one-stop CAR-T therapy development includes everything from biomarker identification and selection to in vitro and in vivo assays, as well as clinical trial design if requested,” according to a scientist. “Our commitment is to ensure that the entire process is carried out with the highest level of quality and efficiency.”
The streamlined workflow relies on the exclusive platforms that light up the route to success and are the rich fruits obtained through batches of customer cases.
* Smart™ CAR Construction
* mRNA-Based CAR Cell Platform
* CAR-T Cell Display Platform
* CRISPR-Edited CAR Cell Technology
* CAR-Stem Cell Platform
* CellRapeutics™ In Vivo Cell Engineering
“I’d like to highlight our in vivo cell engineering service, which leaps beyond conventional ex vivo cell transduction that can be costly and technically challenging,” the scientist added. “Our platform incorporates novel techniques like CRISPR/Cas9 to integrate viral or non-viral vectors with the encoded gene, and then transfects the integration into the body and ends up modifying the immune cells in situ.”
The varieties of cell types accepted for engineering are CAR-T cells, B cells, CAR-NK cells, and CAR-macrophage cells.
Another critical process is to determine if a candidate is fully competent or not-the preclinical CAR-T in vivo assays. Creative Biolabs will work closely with clients to design and execute a customized assay plan, including animal model selection, tumor implantation, CAR-T cell transplantation, and monitoring of therapeutic responses.
“We perform the tests in xenograft murine models derived from well-defined cell lines or primary human tumor cells. Immunodeficient mice are optimal models for engraftment of tumor cells and evaluation of CAR-T cells due to the absence of B cells, T cells, or NK cells. We can also perform the tests in other species as a way of monitoring the progression and remission of tumor cells in any body part throughout the entire treatment duration, obtaining an unambiguous evaluation of the therapeutic efficacy of your candidate cells. In the meantime, we screen out the potential safety concerns, including abnormal cytokine levels and tumorigenicity.” The scientist elaborated.
For CAR-T services, visit https://www.creative-biolabs.com/car-t.
About
Creative Biolabs’ comprehensive CAR-T therapy development solutions have the potential to revolutionize cancer treatment and improve the lives of millions of people. With their cutting-edge technology, experienced team, and commitment to quality, Creative Biolabs is the ideal partner for anyone looking to develop CAR-T therapy.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://www.creative-biolabs.com/car-t