DelveInsight’s, “Renal Cell Carcinoma Pipeline Insight 2023” report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in the Renal Cell Carcinoma pipeline landscape. It covers the Renal Cell Carcinoma pipeline drug profiles, including Renal Cell Carcinoma clinical trials and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key Takeaways from the Renal Cell Carcinoma Pipeline Report
- DelveInsight’s Renal Cell Carcinoma Pipeline analysis depicts a robust space with 30+ active players working to develop 30+ pipeline treatment therapies.
- The leading Renal Cell Carcinoma Companies include AstraZeneca, Infinity Pharmaceuticals, Ipsen, Novartis, Aveao pharmaceuticals, Merck Sharp & Dohme Corp., Pfizer, Bayer Healthcare, Incyte Corporation, GlaxoSmithKline, Bristol-Myers Squibb, Hoffman La Roche, Amgen, ColImmune, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Betta Pharmaceuticals, Regeneron Pharmaceuticals, Cemiplimab, Aravivie Inc, X4 pharmaceuticals, and others.
- Promising Renal Cell Carcinoma Pipeline Therapies include Pexastimogene Devacirepvec (Pexa-Vec), Cemiplimab, lenvatinib, everolimus, Sunitinib, Pembrolizumab, IMP321, Ipilimumab, and others.
- The Renal Cell Carcinoma companies and academics are working to assess challenges and seek opportunities that could influence R&D. Renal Cell Carcinoma The Renal Cell Carcinoma pipeline therapies under development are focused on novel approaches to treat/improve Renal Cell Carcinoma.
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Renal Cell Carcinoma Overview
Renal cell carcinoma (RCC) is also called hypernephroma, renal adenocarcinoma, or renal or kidney cancer. Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. In early stages Renal carcinoma is symptom free but as the diseases progresses the symptoms may include: lump in the abdomen, fatigue, and unexplained weight loss, blood in the urine, loss of appetite, vision problem, and excessive hair growth.
Recent Development Activities in the Renal Cell Carcinoma Treatment Landscape
- In November 2021, HUTCHMED Limited and AstraZeneca PLC initiated SAMETA, a global Phase III study of savolitinib (ORPATHYS® in China), an oral, potent, and highly selective small-molecule inhibitor of MET, a receptor tyrosine kinase, in combination with AstraZeneca’s PD-L1 inhibitor IMFINZI® (durvalumab) in patients with MET-driven advanced papillary renal cell carcinoma (“PRCC”).
- In August 2021, Exelixis, Inc. announced Takeda Pharmaceutical Company Limited (Takeda), its partner responsible for the clinical development and commercialisation of CABOMETYX® (cabozantinib) in Japan, and Ono Pharmaceutical Co., Ltd. (Ono) received approval from the Japanese Ministry of Health, Labor and Welfare to manufacture and market CABOMETYX in combination with OPDIVO® (nivolumab) as a treatment for unresectable or metastatic renal cell carcinoma (RCC).
- In August 2021, Merck, known as MSD outside the United States and Canada, announced that the U.S. Food and Drug Administration (FDA) has accepted and granted priority review for a new supplemental Biologics License Application (sBLA) for KEYTRUDA, Merck’s anti-PD-1 therapy, for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy (surgical removal of a kidney), or following nephrectomy and resection of metastatic lesions.
- In July 2021, Arrowhead Pharmaceuticals Inc. announced positive interim results from the first two cohorts of AROHIF21001, a Phase 1b dose-finding clinical studies of ARO-HIF2, the company’s investigational RNA interference (RNAi) therapeutic being developed as a treatment for patients with clear cell renal cell carcinoma (ccRCC).
For further information, refer to the detailed Renal Cell Carcinoma Drugs Launch, Renal Cell Carcinoma Developmental Activities, and Renal Cell Carcinoma News, click here for Renal Cell Carcinoma Ongoing Clinical Trial Analysis
Renal Cell Carcinoma Emerging Drugs Profile
- CM082: Betta Pharmaceuticals
CM082 series have the similar skeletal structures to Icotinib Hydrochloride, as the multi-target RTK (receptor tyrosine kinase) inhibitor, mainly targeting at VEGFR and PDGFR. The drug is being evaluated in phase III stage of development for the treatment of Renal Cell Carcinoma.
- TQB 2450: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
TQB 2450 (formerly APL 502 and CBT 502) is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1. Phase III clinical trials are being evaluated by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. for TQB 2450 for the treatment of renal cell carcinoma.
- IPI-549: Infinity Pharmaceuticals
IPI-549 is an oral immuno-oncology candidate which has been designed to preferentially inhibit PI3K-gamma. The drug is being studied in phase II stage of development for the treatment of renal cell carcinoma.
- CMN-001: ColImmune
Dendritic cells have been used by colimmune for the treatment of renal failure. CMN001 is a dendritic cell vaccine for renal cell carcinoma. The drug is being evaluated in phase II stage of development for the treatment of renal cell carcinoma.
Renal Cell Carcinoma Pipeline Therapeutics Assessment
There are approx. 30+ key companies which are developing the therapies for Renal Cell Carcinoma. The companies which have their Renal Cell Carcinoma drug candidates in the most advanced stage, i.e. phase III include, Betta Pharmaceuticals.
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Scope of the Renal Cell Carcinoma Pipeline Report
- Coverage- Global
- Renal Cell Carcinoma Companies- AstraZeneca, Infinity Pharmaceuticals, Ipsen, Novartis, Aveao pharmaceuticals, Merck Sharp & Dohme Corp., Pfizer, Bayer Healthcare, Incyte Corporation, GlaxoSmithKline, Bristol-Myers Squibb, Hoffman La Roche, Amgen, ColImmune, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Betta Pharmaceuticals, Regeneron Pharmaceuticals, Cemiplimab, Aravivie Inc, X4 pharmaceuticals, and others.
- Renal Cell Carcinoma Pipeline Therapies- Pexastimogene Devacirepvec (Pexa-Vec), Cemiplimab, lenvatinib, everolimus, Sunitinib, Pembrolizumab, IMP321, Ipilimumab, and others.
- Renal Cell Carcinoma Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration
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Table of Content
- Introduction
- Executive Summary
- Renal Cell Carcinoma: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Renal Cell Carcinoma – DelveInsight’s Analytical Perspective
- In-depth Commercial Assessment
- Renal Cell Carcinoma Collaboration Deals
- Late Stage Products (Phase III)
- TQB 2450: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- IPI-549: Infinity Pharmaceuticals
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- AVB-S6-500: Aravive Inc.
- Drug profiles in the detailed report…..
- Preclinical Stage Products
- Drug Name: Company name
- Drug profiles in the detailed report…..
- Inactive Products
- Renal Cell Carcinoma Key Companies
- Renal Cell Carcinoma Key Products
- Renal Cell Carcinoma – Unmet Needs
- Renal Cell Carcinoma – Market Drivers and Barriers
- Renal Cell Carcinoma – Future Perspectives and Conclusion
- Renal Cell Carcinoma Analyst Views
- Renal Cell Carcinoma Key Companies
- Appendix
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