MARKET DYNAMICS:
The global electroporation instruments and consumables market growth is driven by public and private bodies’ increasing research and development funding. In addition, the increase in the technological advancements in nanotechnology, biotechnology, and pharmacology, increases its penetration rates.
Progress in gene editing techniques is expected to drive growth in the forecast period.
The advancements in gene-editing technologies, including regularly- interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins or transcription activator-like effector nucleases (TALENs), have enabled the researchers to curate targeted sequence-specific changes across the DNA– a factor that is expected to rise the adoption of electroporation instruments. As the advancements in gene-editing techniques occur steadily, the prospects of this market continue to look at a bright future.
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Moreover, as applications of gene editing techniques continue to increase research and development, the adoption of electroporation instruments is likely to witness considerable growth. In addition, significant advancements in the electroporation instruments and electrodes coupled with the increasing compatibility with cutting-edge gene-editing technology are likely to play a vital role in the overall development of the global electroporation instruments and consumables market.
For instance, in June 2018, the first genome editing method for R. eutropha using an electroporation-based CRISPR-Cas9 approach was presented in the research. This method significantly increased the efficiency and decreased the time to manipulate this facultative chemolithoautotrophic microbe. The novel technique will facilitate more advanced studies and applications of R. eutropha for PHA production and CO2 conversion.
Non-specific transport and other complications are expected to drive the growth in the forecast period.
When compared to other delivery systems, electroporation methods have few drawbacks. In some situations, non-specific material transport can cause an ion imbalance, leading to cellular dysfunction and death. Irreversible electroporation, which is usually regarded as an unusual cell death method, could result in the loss of cell homeostasis. The electroporation method causes complications and skin edema compared to other physical processes. In other chemical methods, instruments are not required, which are highly preferred by some researchers. However, in some instances, electroporation effectiveness is widely influenced by other factors such as cell or tissue type and DNA formulation.
Moreover, the major drawback of electroporation is substantial cell death caused by high voltage pulses and only partially successful membrane repair, requiring the use of more significant quantities of cells compared to chemical transfection methods. Several laboratories have reported the harmful effects of electroporation on cells due to local pH changes, the emergence of toxic electrode products, temperature increases, and the heterogeneity of the electric field operating on cells in the cuvettes used for electroporation.InvitrogenNeon Transfection System by Thermo Fisher overcomes high cell mortality by distributing the electrical pulse equally among the cells and maintaining a stable pH throughout the electroporation chamber. However, optimizing pulse and field strength parameters is still required to balance the electroporation efficiency and cell viability.
COVID-19 Impact Analysis:
The impact of the COVID-19 pandemic on the global electroporation instruments & consumables market is expected to remain moderate in 2020, as research and development activities are likely to remain unaffected.
Furthermore, the increasing adoption of gene-editing technology across the healthcare sector worldwide is likely to continue in 2020. The electroporation instruments & consumables market is projected to witness steady growth. As precision medicines play an imperative role in assisting researchers and scientists in evaluating the novel coronavirus, the demand for electroporation instruments is likely to grow. In addition, CRISPR-based diagnostics are increasingly being used to accurately diagnose a range of medical diseases, including the novel COVID-19 infection, another factor that is expected to propel the market’s growth for electroporation instruments during the pandemic. Electroporation has been shown to impact vaccine immunogenicity and efficacy significantly. This is because it can increase antigen delivery as much as 1000-fold over naked DNA delivery technologies alone. This increased delivery translates to an improved immune response magnitude and improved response rates relative to DNA delivery by direct injection alone. Electroporation is accomplished through a sterile, disposable needle array attached to an applicator. The DNA plasmid of interest is delivered separately via intradermal or intramuscular needle injection to an area marked by the electrodes immediately before the electroporation treatment. The electroporation treatment is achieved by introducing an electrical pulse/s of defined magnitude and length to the cells of interest.
SEGMENT ANALYSIS:
The entire electroporation system segment is expected to hold the largest share in this market segment.
The total electroporation system is the complete electroporation system for the transfection of both eukaryotic and prokaryotic cells. The system features adjustable delivery parameters, including a time constant, the actual voltage applied, pulse interval, and pulse time, depending on the waveform chosen. Total Electroporation systems are flexible systems allowing both square wave and exponential decay wave electroporation in a single unit. These waveform combinations enable researchers to efficiently electroporate eukaryotic and prokaryotic cells in cuvettes or plates with one easy-to-use setup. With a wide range of pulsing parameters, advanced safety features, and dozens of preset protocols, a total electroporation system can be used in any lab requiring efficient cell transfection or transformation without the use of costly reagents. These systems incorporate remote operation functionality via footswitch or PC and internal log storage of experiment data for easy optimization, quality control requirements and troubleshooting. It allows researchers to select which type of waveform they would use to transfect eukaryotic cells or transform prokaryotic cells. Typically, eukaryotic cells respond best to square wave pulses, while prokaryotic cells respond well to exponential decay wave pulses. Combining these two waveforms gives researchers total flexibility to achieve the highest efficiency for their application.
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GEOGRAPHICAL ANALYSIS:
The North American region holds the largest market share of global electroporation instruments and consumables.
The North American region dominated the global electroporation instruments & consumables market, followed by Europe. The rise in cancer and autoimmune diseases in North America fueled the market. The advanced healthcare infrastructure coupled with rapid advancements in technology is expected to play an imperative role in boosting the growth of these region electroporation instruments & consumables markets. Moreover, the approval rate of electroporation instruments across Europe and North America is comparatively higher than that across the Asia Pacific.
As per the World Health Organization (WHO), cancer is the second-most leading cause of death worldwide, accounting for over 18.1 million cases were diagnosed in 2018. In 2020, around 19 Mn new cancer cases were analyzed worldwide as per the WHO. Likewise, the American Cancer Society reported that 89,500 cases were diagnosed in the U.S. in 2020. Additionally, according to International Agency for Research on Cancer (IARC) estimates, by 2040, global cancer cases are expected to grow to 27.5 million new cancer cases worldwide. This number has led to an increase in various electroporation methods.
COMPETITIVE LANDSCAPE:
The global electroporation instruments and consumables market is highly competitive with the presence of local and international companies. Some of the key players contributing to the market’s growth include Thermo Fisher Scientific Inc, Bio-Rad Laboratories, BEX Co. Ltd, Celetrix LLC, Merck KGaA, Eppendorf AG Harvard Bioscience Inc. (BTX), MaxCyte Inc, Lonza Group, Mirus Bio LLC. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, contributing to the growth of wound care management devices globally. For instance, In August 2021, MaxCyte signed a clinical and commercial license with Sana Biotechnology. The agreement represents MaxCyte’s 14th strategic platform license (SPL). Sana will use MaxCyte’s Flow Electroporation technology and ExPERT platform in conjunction with the development of its hypoimmune cell therapy programs.
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