DelveInsight’s ‘Refractory Multiple Myeloma Pipeline Insight 2022‘ report provides comprehensive global coverage of available, marketed, and pipeline refractory multiple myeloma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the refractory multiple myeloma pipeline domain.
The increasing incidence, rise in healthcare investments, and a number of diagnoses among patients are driving the growth of the market. Major players that are developing potential therapies in the late stage of development include Janssen Research & Development, LLC, MorphoSys/ I-Mab Biopharma, Rapa Therapeutics, Arcellx, Inc., Novartis, and several others.
Key Takeaways from the Refractory Multiple Myeloma Pipeline Report
- DelveInsight’s refractory multiple myeloma pipeline report depicts a robust space with 80+ active players working to develop 80+ pipeline therapies for refractory multiple myeloma treatment.
- Key refractory multiple myeloma companies such as NexImmune, Amgen, AbbVie, Allogene Therapeutics, Precision Biosciences, Takeda Oncology, ORIC Pharmaceuticals, Ionis Pharmaceuticals, Cellectis S.A., YZY Biopharma, Janssen Research & Development, Bristol Myers Squibb, Lava Therapeutics, Prelude Therapeutics, Amgen, Pfizer, Rapa Therapeutics, Arcellx, Inc., Gilead Sciences, Novartis, Celgene Corporation, Genmab, Harpoon Therapeutics, Cytovia Therapeutics, Ichnos Sciences, Poseida Therapeutics, Allogene Therapeutics, Seagen Inc., Regeneron Pharmaceuticals, CFT7455, C4 Therapeutics, CARsgenTherapeutics Co.,Ltd, CELLECTAR BIOSCIENCES, INC., Nektar Therapeutics, iTeos Therapeutics, CASI Pharmaceuticals, Fate Therapeutics, Actinium Pharmaceuticals, Inc., Molecular Templates, Inc., NexImmune, Inc., LAVA Therapeutics, Sorrento Therapeutics, Chimerix, Ascentage Pharma Group Inc., Keymed Biosciences, MiNK Therapeutics, and others are evaluating new drugs for refractory multiple myeloma to improve the treatment landscape.
- Promising refractory multiple myeloma pipeline therapies in various stages of development include NEXI 002, AMG-701, ABBV 453, ALLO-605, PBCAR269A, TAK-981, ABBV-383, ORIC-533, agenT-797, ION251, UCARTCS1A, Y150, Talquetamab, Ipilimumab, LAVA-051, Felzartamab, Elranatamab, RAPA-201, CART-ddBCMA, Magrolimab, PHE885, Marizomib, Teclistamab, HPN-217, CYT-338, ISB 1342, P-BCMA-ALLO1, ALLO-715, ALLO-605, SEA-BCMA, REGN5458, NKTR-255, Iopofosine, EOS-448, CID-103, FT538, MT-0169, NEXI-002, LAVA-051, STI-6129, ONC201, APG-2575, CM336, agenT-797, and others.
- In August 2022, Ipsen announced the closing of the definitive merger agreement under which Ipsen has acquired Epizyme, Inc. (Epizyme). Pursuant to the transaction, Ipsen acquires all outstanding shares of Epizyme for $1.45 per share plus a contingent value right (CVR) of $1.00 per share. Epizyme now operates as ‘an Ipsen company’ at the deal close.
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The refractory multiple myeloma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage refractory multiple myeloma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the refractory multiple myeloma clinical trial landscape.
Refractory Multiple Myeloma Overview
Multiple myeloma is a type of cancer that begins in a type of white blood cell known as a plasma cell. It’s rare, accounting for less than 2% of all plasma cell tumors, but it’s the most common type, according to the CDC. Although the survival rate of multiple myeloma has improved in recent years, initial refractory multiple myeloma treatment is still ineffective in the vast majority of cases. If myeloma is resistant to treatment or becomes resistant during treatment, it is said to be refractory.
The refractory multiple myeloma symptoms are the same as those of multiple myeloma. These refractory multiple myeloma symptoms either persist or return after treatment. The most common refractory multiple myeloma symptom is bone pain.
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Refractory Multiple Myeloma Therapeutics Assessment
The refractory multiple myeloma pipeline report proffers an integral view of the refractory multiple myeloma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Refractory Multiple Myeloma Pipeline Report
- Coverage: Global
- Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
- Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Ophthalmic, Intravenous, Oral, Subcutaneous, Topical, Parenteral, Transdermal
- Therapeutics Assessment By Molecule Type: Oligonucleotide, Small molecule, Peptide
- Therapeutics Assessment By Mechanism of Action: Antibody-dependent cell cytotoxicity, Cytotoxic T lymphocyte stimulants, Immunologic cytotoxicity, Small ubiquitin-related modifier protein inhibitors, Natural killer cell replacements, Proto-oncogene protein c-bcl-2 inhibitors
- Key Refractory Multiple Myeloma Companies: NexImmune, Amgen, AbbVie, Allogene Therapeutics, Precision Biosciences, Takeda Oncology, ORIC Pharmaceuticals, Ionis Pharmaceuticals, Cellectis S.A., YZY Biopharma, Janssen Research & Development, Bristol Myers Squibb, Lava Therapeutics, Prelude Therapeutics, Amgen, Pfizer, Rapa Therapeutics, Arcellx, Inc., Gilead Sciences, Novartis, Celgene Corporation, Genmab, Harpoon Therapeutics, Cytovia Therapeutics, Ichnos Sciences, Poseida Therapeutics, Allogene Therapeutics, Seagen Inc., Regeneron Pharmaceuticals, CFT7455, C4 Therapeutics, CARsgenTherapeutics Co.,Ltd, CELLECTAR BIOSCIENCES, INC., Nektar Therapeutics, iTeos Therapeutics, CASI Pharmaceuticals, Fate Therapeutics, Actinium Pharmaceuticals, Inc., Molecular Templates, Inc., NexImmune, Inc., LAVA Therapeutics, Sorrento Therapeutics, Chimerix, Ascentage Pharma Group Inc., Keymed Biosciences, MiNK Therapeutics, and others.
- Key Refractory Multiple Myeloma Pipeline Therapies: NEXI 002, AMG-701, ABBV 453, ALLO-605, PBCAR269A, TAK-981, ABBV-383, ORIC-533, agenT-797, ION251, UCARTCS1A, Y150, Talquetamab, Ipilimumab, LAVA-051, Felzartamab, Elranatamab, RAPA-201, CART-ddBCMA, Magrolimab, PHE885, Marizomib, Teclistamab, HPN-217, CYT-338, ISB 1342, P-BCMA-ALLO1, ALLO-715, ALLO-605, SEA-BCMA, REGN5458, NKTR-255, Iopofosine, EOS-448, CID-103, FT538, MT-0169, NEXI-002, LAVA-051, STI-6129, ONC201, APG-2575, CM336, agenT-797, and others.
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Table of Contents
- Introduction
- Executive Summary
- Refractory Multiple Myeloma: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Refractory Multiple Myeloma– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Mid Stage Products (Phase I/II)
- NEXI 002: NexImmune
- Early Stage Products (Phase I)
- ABBV 453: AbbVie
- Preclinical and Discovery Stage Products
- Inactive Products
- Refractory Multiple Myeloma Key Companies
- Refractory Multiple Myeloma Key Products
- Refractory Multiple Myeloma- Unmet Needs
- Refractory Multiple Myeloma- Market Drivers and Barriers
- Refractory Multiple Myeloma- Future Perspectives and Conclusion
- Refractory Multiple Myeloma Analyst Views
- Refractory Multiple Myeloma Key Companies
- Appendix
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