DelveInsight’s “Chronic Lymphocytic Leukemia Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of Chronic Lymphocytic Leukemia (CLL), historical and forecasted epidemiology as well as the Chronic Lymphocytic Leukemia (CLL) market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
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Key Takeaways from the Chronic Lymphocytic Leukemia Market Report
- In January 2025:- AbbVie- A Prospective, Open-Label, Phase IIb/III Study to Evaluate the Risk of TLS and Optimization of the Initiation of Venetoclax in Combination With Obinutuzumab or Acalabrutinib With Different Ramp- Up Periods in Previously Untreated Subjects With CLL. Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety of venetoclax in combination with obinutuzumab or acalabrutinib in the treatment of CLL. Adverse events and change in disease activity will be assessed.
- The median age of patients at the time of diagnosis is 71 years, and > 95% of CLL patients are over 50 years old.
- CLL accounts for about one-quarter of the new cases of leukemia. The average person’s lifetime risk of getting CLL is about 1 in 175 (0.57%).
- The male predominance is marked, with ~60% of CLL cases identified in men and ~40% of cases identified in women.
- The leading Chronic Lymphocytic Leukemia Companies such as Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, Starton Therapeutics, TG Therapeutics, Bristol Myers Squibb, Novartis, Aprea Therapeutics, AstraZeneca, Genor Biopharma, Incyte Corporation, MorphoSys, Astex Therapeutics, Lava Therapeutics, Celgene Corporation, and others.
- Promising Chronic Lymphocytic Leukemia Therapies such as Obinutuzumab, Rituximab, Chlorambucil, Acalabrutinib, and others.
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Chronic Lymphocytic Leukemia Epidemiology Segmentation in the 7MM
- Incident Cases of Chronic Lymphocytic Leukemia
- Gender-specific Cases of Chronic Lymphocytic Leukemia
- Age-specific Cases of Chronic Lymphocytic Leukemia
- Mutation-specific Cases of Chronic Lymphocytic Leukemia
- Stage-specific Cases of Chronic Lymphocytic Leukemia
- Treated Cases of Chronic Lymphocytic Leukemia
- Relapsed and Refractory Cases of Chronic Lymphocytic Leukemia
Download the report to understand which factors are driving Chronic Lymphocytic Leukemia epidemiology trends @ Chronic Lymphocytic Leukemia Prevalence
Chronic Lymphocytic Leukemia Marketed Drugs
- BREYANZI: Bristol Myers Squibb
BREYANZI (lisocabtagene maraleucel; liso-cel) is a CD19-directed chimeric antigen receptor (CAR) T-cell therapy developed by Bristol Myers Squibb.
In March 2024, Bristol Myers Squibb received accelerated FDA approval for BREYANZI for adult patients with relapsed or refractory CLL /SLL who’ve had at least two prior lines of therapy, including a BTK inhibitor and a BCL-2 inhibitor. BREYANZI has shown a consistent safety profile across clinical trials, with a response rate of 95.7% and a median duration of response not reached, with 77.1% of responders still in remission at 18 months.
- IMBRUVICA: AbbVie/Johnson & Johnson
IMBRUVICA (Ibrutinib) by AbbVie and Johnson & Johnson Innovative Medicine was approved by the US FDA in April 2020 in combination with rituximab for the initial treatment of adult patients with CLL/SLL. IMBRUVICA is the only Bruton’s tyrosine kinase inhibitor (BTKi) approved with an oral suspension formulation, providing additional flexibility for patients who may have difficulty swallowing tablets or capsules. This flexibility is particularly important for patients with CLL or Waldenström’s macroglobulinemia (WM).
Chronic Lymphocytic Leukemia Emerging Drugs
- Nemtabrutinib: Merck Sharp & Dohme
Nemtabrutinib is an investigational reversible, non-covalent BTK inhibitor that is being studied for the suppression of oncogenic B-cell receptor signaling with activity against wild-type BTK and BTK pathway mutants. Nemtabrutinib was acquired as part of the acquisition of ArQule. Currently, the company is conducting a Phase III (NCT05624554) clinical trial of nemtabrutinib to compare the efficacy and safety of nemtabrutinib versus chemoimmunotherapy for previously untreated CLL/SLL without TP53 aberrations.
- Lisaftoclax (APG-2575): Ascentage Pharma
Lisaftoclax is an orally active, highly selective small molecule antagonist of BCL-2. APG-2575 induces cellular apoptosis through selective disruption of the interaction of anti-apoptotic protein BCL-2 with pro-apoptotic proteins such as BIM. The drug is in development as a single agent or as a component of combination therapy in patients with CLL/SLL. Lisaftoclax has been granted ODD by the US FDA for the treatment of CLL.
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Chronic Lymphocytic Leukemia Therapeutics Market
This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2024–2034, which depends on the competitive landscape, safety, and efficacy data along with order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.
Scope of the Chronic Lymphocytic Leukemia Market Report
- Coverage- 7MM
- Study Period- 2020-2034
- Chronic Lymphocytic Leukemia Companies- Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, Starton Therapeutics, TG Therapeutics, Bristol Myers Squibb, Novartis, Aprea Therapeutics, AstraZeneca, Genor Biopharma, Incyte Corporation, MorphoSys, Astex Therapeutics, Lava Therapeutics, Celgene Corporation, and others.
- Chronic Lymphocytic Leukemia Therapies- Obinutuzumab, Rituximab, Chlorambucil, Acalabrutinib, and others.
- Chronic Lymphocytic Leukemia Therapeutic Assessment: Chronic Lymphocytic Leukemia current marketed and Chronic Lymphocytic Leukemia emerging therapies
- Chronic Lymphocytic Leukemia Market Dynamics: Chronic Lymphocytic Leukemia market drivers and Chronic Lymphocytic Leukemia market barriers
- Chronic Lymphocytic Leukemia Unmet Needs, KOL’s views, Analyst’s views, Chronic Lymphocytic Leukemia Market Access and Reimbursement
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Table of Content
1. Key Insights
2. Report Introduction
3. Chronic Lymphocytic Leukemia (CLL) Market Overview at a Glance
4. Executive Summary of Chronic Lymphocytic Leukemia (CLL)
5. Key Events
6. Epidemiology and Market Methodology
7. Disease Background and Overview
8. Treatment and Management of Chronic Lymphocytic Leukemia (CLL)
9. Epidemiology and Patient Population
10. Patient Journey
11. Marketed Therapies
12. Emerging Therapies
13. Chronic Lymphocytic Leukemia (CLL) Disease: 7 Major Market Analysis
14. KOL Views
15. SWOT Analysis
16. Unmet Needs
17. Market Access and Reimbursement
18. Appendix
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight
About Us
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