Leptomeningeal Metastases Treatment Market is projected to witness substantial growth over the next few years, driven by advancements in treatment modalities and increasing awareness of the condition. The pipeline for Leptomeningeal Metastases Therapeutics includes promising candidates that aim to not only treat acute attacks but also prevent recurrence.
DelveInsight’s “Leptomeningeal Metastases Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of the Leptomeningeal Metastases, historical and forecasted epidemiology as well as the Leptomeningeal Metastases Market Trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
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Key Takeaways from the Leptomeningeal Metastases Market Report
- In September 2024:- UNICANCER- The goal of this clinical trial is to evaluate the efficacy of tucatinib and capecitabine in combination with intrathecal trastuzumab on overall survival rate at 12 months in HER2-positive metastatic breast cancer (MBC) patients with proven leptomeningeal evolution and requiring intrathecal therapy.
- In September 2024:- MedSIR- Multicenter, Single-arm, 3 Cohort, Phase II Trial of HER3-DXd in Patients With Active Brain Metastases From Metastatic Breast Cancer and Non-small Cell Lung Cancer, and in Patients With Leptomeningeal Disease From Advanced Solid Tumors.
- According to the Nayar et al. (2017), in the United States, 1–8% of cancer patients are diagnosed with LMD, with approximately 110,000 cases of LMD per year in the US. LMD is found in 1–5% of patients with solid tumors, and 1–2% of patients with primary brain tumors. The exact incidence of LMD is difficult to determine, since gross examination at autopsy may overlook signs of LMD, and microscopic pathological inspection may be normal if the seeding is multifocal or if an unaffected area of the CNS is examined.
- According to the Chamberlain et al., LM occurs in 4±15% of patients with solid tumors, 7±15% of patients with lymphomas, 5±15% of patients with leukemias and 1±2% of patients with primary brain tumors. Solid tumors are disproportionately represented in clinical series of patients with NM due to their high frequency of occurrence, wherein breast (range of tumor-specific occurrence 12±34%), lung (range of tumor-specific occurrence 10±26%), melanoma (range of tumor-specific occurrence 17±25%).
- According to the Association of Cancer Care (2024), the highest frequency of leptomeningeal metastasis (LM) is observed in melanoma, affecting 22-46% of cases. This is followed by small cell lung cancer, breast cancer, non-small cell lung cancer, and head and neck cancers. Additionally, brain parenchymal metastases may be linked to leptomeningeal disease in as many as 82% of cases.
- As per the DelveInsight estimates, nearly 70% patients were in low risk patient pool in the United States and nearly 70% patients were taking treatment for leptomeningeal metastases.
- As per the DelveInsight estimates, in the year 2023, the total diagnosed cases of Leptomeningeal Metastases were ~300,000 cases in the 7MM, which are expected to grow during the study period, i.e., 2020-2034.
- The leading Leptomeningeal Metastases Companies such as Plus Therapeutics, AstraZeneca, Angiochem, Y-mAbs Therapeutics, and others.
- Promising Leptomeningeal Metastases Therapies such as ANG1005, Pertuzumab, Trastuzumab, TY-9591, Trastuzumab deruxtecan, and others.
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Leptomeningeal Metastases Epidemiology Segmentation in the 7MM
- Total Leptomeningeal Metastases Diagnosed Cases
- Total Leptomeningeal Metastases Incident Cases of Different Cancer Types Associated
- Total Leptomeningeal Metastases Cancer-specific Cases
- Total Leptomeningeal Metastases Treated Cases
Leptomeningeal Metastases Treatment Market
The primary goals of treatment for leptomeningeal metastasis (LM) are to alleviate neurological symptoms, stabilize or improve neurological function, and prolong survival. Prognosis varies significantly based on the primary tumor type and the extent of neurological and systemic disease, making it essential to identify parameters that differentiate poor-risk from good-risk patients to guide therapeutic decisions. For patients with poor prognosis—characterized by a low quality of life, fixed neurological deficits, encephalopathy from extensive LM-brain infiltration, and uncontrolled systemic disease—a palliative approach is recommended, even with LM-directed treatment. Regardless of treatment choices, supportive care is crucial for managing neurological symptoms in all LM patients.
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Leptomeningeal Metastases Emerging Drugs
- ANG1005: Angiochem
Paclitaxel trevatide (ANG1005) is a peptide-drug conjugate developed by Angiochem, combining paclitaxel with a peptide (Angiopep-2) designed to traverse the blood-brain barrier and blood-cerebrospinal fluid barrier (BCB) via the LRP-1 transport system. This approach aims to overcome the limitations imposed by the efflux pump P-glycoprotein (P-gp), which typically prevents paclitaxel from effectively reaching its target within the central nervous system. ANG1005 is currently under investigation in a Phase III trial (NCT03613181) for the treatment of leptomeningeal carcinomatosis.
Leptomeningeal Metastases Market Outlook
The market for leptomeningeal metastases is increasingly optimistic due to rising rates and growing demand for effective treatments. The factors contributing to the growth of the LM market are certain advancements in diagnostic technologies, such as advanced imaging and cerebrospinal fluid analysis, which are crucial for early detection and management of leptomeningeal metastases. The development of novel therapies like Rhenium-186 NanoLiposome and ANG1005, alongside precision radiation techniques, promises to transform treatment options. Despite these advances, challenges remain, such as the lack of approved therapies and the need for more robust clinical trial data.
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Scope of the Leptomeningeal Metastases Market Report
- Coverage- 7MM
- Leptomeningeal Metastases Companies- Plus Therapeutics, AstraZeneca, Angiochem, Y-mAbs Therapeutics, and others.
- Leptomeningeal Metastases Therapies- ANG1005, Pertuzumab, Trastuzumab, TY-9591, Trastuzumab deruxtecan, and others.
- Leptomeningeal Metastases Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Leptomeningeal Metastases Unmet Needs, KOL’s views, Analyst’s views, Leptomeningeal Metastases Market Access and Reimbursement
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Table of Content
1 Key Insights
2 Report Introduction
3 Executive Summary of Leptomeningeal Metastases (LM)
4 Key Events
5 LM Epidemiology and Market Forecast Methodology
6 LM Market Overview at a Glance
7 Disease Background and Overview: LM
8 Treatment and Management
9 Epidemiology and Patient Population of LM in the 7MM
10 Patient Journey
11 Key Endpoints in LM
12 Emerging Therapies
14 LM: Seven Major Market Analysis
15 Unmet Needs
16 SWOT Analysis
17 KOL Views
18 Market Access and Reimbursement
19 Appendix
20 DelveInsight Capabilities
21 Disclaimer
22 About DelveInsight
About Us
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