New York, USA – July 24, 2024 – Live biotherapeutic products (LBPs) are gaining attention for their health benefits through various mechanisms. However, developing and applying these products pose several challenges, such as ensuring microbial sensitivity and resistance to antibiotics and maintaining their activity and stability. Creative Biolabs offers analytical development and certification services for LBPs to accelerate drug development for clients worldwide.
Antimicrobial Sensitivity Testing: Ensuring Microbial-Antibiotic Synergy
A significant application of LBPs is their use in conjunction with antibiotics, making it crucial to understand the antibiotic susceptibility of microorganisms. “Drug sensitivity and resistance can be assessed through different methods, and we employ such approaches,” explains an expert from Creative Biolabs.
Creative Biolabs designs multiple solutions to assess the drug sensitivity of LBP products, offering comprehensive sensitivity spectrum analyses:
* Minimum Inhibitory Concentration Testing
* Disk Diffusion Method
* Antimicrobial Resistance Gene Analysis
“These methods provide quick and precise evaluations of microbial responses to different antibiotics, enabling clients to select the optimal antibiotic combinations to enhance therapeutic efficacy. Additionally, cross-validation techniques ensure high accuracy and reliability of the test results.”
In addition to traditional phenotypic methods, Creative Biolabs also utilizes advanced genotypic methods to detect microbial sensitivity to antibiotics. These methods provide a more comprehensive assessment of resistance by analyzing specific genes or mutations in the microbial genome. For instance:
* Polymerase Chain Reaction
* DNA Microarray
* SmartChip System
Microbial Stabilization: Ensuring Activity and Stability
Maintaining microbial activity and stability during the development of live biotherapeutic products is a critical challenge. Creative Biolabs assists in sample selection, characterization of LBP products, and the design of stability testing protocols for different strains.
Creative Biolabs also supports refrigerated and frozen storage of products, further extending microbial survival and stability by adjusting environmental conditions (such as pH and osmotic pressure) and using protective agents to ensure that products retain their expected performance when transferred to large-scale formulators or manufacturers.
“We understand that ensuring the drug sensitivity, stability, and safety of live biotherapeutic products is key to success,” the expert notes. “Thus, we offer the most advanced technology and comprehensive services to help researchers with validation and testing, supporting their success in their projects.”
For more information about sensitivity and stability testing services for LBP products, please visit https://live-biotherapeutic.creative-biolabs.com.
About Creative Biolabs
Creative Biolabs is a leading biotechnology company, providing innovative research and development services and product solutions in antibody development, cell therapy, gene editing, and microbiology. From September 3rd to 5th, Creative Biolabs will present its latest solutions at the 15th Annual World Bispecific Summit, engaging with researchers from around the world to discuss innovations in the field.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://live-biotherapeutic.creative-biolabs.com