DelveInsight’s “Limb Girdle Muscular Dystrophy (LGMD) Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Limb Girdle Muscular Dystrophy market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging Limb Girdle Muscular Dystrophy drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Limb Girdle Muscular Dystrophy treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Limb Girdle Muscular Dystrophy (LGMD): An Overview
Muscular dystrophy is a group of conditions that damage and weaken one’s muscles over time. due to the lack of a protein called dystrophin, which is necessary for typical muscle function. A deficiency of this protein can cause problems with walking, swallowing, and muscle coordination, among other symptoms.
Limb-girdle muscular dystrophies (LGMD) also known as pelvofemoral muscular dystrophy or proximal muscular dystrophy is a type of muscular dystrophy and they are a group of rare progressive genetic disorder that is characterized by wasting (atrophy) and weakness of the voluntary muscles of the hip and shoulder areas (limb-girdle area). Muscle weakness and atrophy are progressive and may spread to affect other muscles of the body. The various forms of limb-girdle muscular dystrophy are caused by mutations in many different genes. These genes provide instructions for making proteins that are involved in muscle maintenance and repair.
The age at onset, severity, and progression of symptoms of LGMD may vary greatly from case to case, even among individuals in the same family. Some individuals may have a mild, slowly progressive form of the disorder; others may have a rapidly progressive form of the disorder that causes severe disability. Males and females are affected in equal numbers.
No cure exists for any form of LGMD. Treatment is aimed at the specific symptoms present in each individual. Specific treatment options may include physical and occupational therapy to improve muscle strength and prevent contractures. Various devices (e.g., canes, braces, walkers, wheelchairs) are used to assist with walking; Surgery to correct skeletal abnormalities; and regular monitoring of the heart and the respiratory system for the development of such complications potentially associated with some forms of LGMD. Genetic counseling may be of benefit to affected individuals and their families. Other treatments are symptomatic and supportive.
Limb Girdle Muscular Dystrophy (LGMD) Market Key Facts
- Autosomal recessive LGMDs (LGMDR) are more common than the autosomal dominant forms of the disease (LGMDD), which probably account for about 10% of all LGMDs. The age at onset, severity, and progression of symptoms of the subtypes may vary greatly from case to case, even among individuals in the same family. Some individuals may have a mild, slowly progressive form of the disorder; others may have a rapidly progressive form of the disorder that causes severe disability.
- According to the research conducted by Moran et al. (2018), in the UK, LGMD is considered the second most common muscular dystrophy after dystrophinopathies, with prevalence of up to 1:14,500 and a carrier frequency of up to 1:150.
- According to a study conducted by Wang et. al. (2018), LGMD is the fourth most common muscular dystrophy, with a pooled prevalence of 1.63 per 100,000 people, following myotonic dystrophy, dystrophinopathy, and facioscapulohumeral dystrophy. The prevalence varies among subtypes and regions.
- As per Angelini Corrado et al. (2017), calpainopathy has a prevalence of approximately 1:100,000 inhabitants, southern Italy estimated the prevalence of calpainopathy at 1:42,700 inhabitants.
Limb Girdle Muscular Dystrophy (LGMD) Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Limb Girdle Muscular Dystrophy pipeline therapies. It also thoroughly assesses the Limb Girdle Muscular Dystrophy market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete details of the market trend for each marketed Limb Girdle Muscular Dystrophy drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Limb Girdle Muscular Dystrophy (LGMD) Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted Limb Girdle Muscular Dystrophy epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted Limb Girdle Muscular Dystrophy epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the Limb Girdle Muscular Dystrophy (LGMD) Epidemiology, Segmented as –
- Prevalent Cases of Limb Girdle Muscular Dystrophy (LGMD) in the 7MM [2019–2032]
- Diagnosed Prevalent Cases of Limb Girdle Muscular Dystrophy (LGMD) in the 7MM [2019–2032]
- Treatable Cases of Limb Girdle Muscular Dystrophy (LGMD) in the 7MM [2019–2032]
Limb Girdle Muscular Dystrophy (LGMD) Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Limb Girdle Muscular Dystrophy market or expected to be launched during the study period. The analysis covers the Limb Girdle Muscular Dystrophy market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the Limb Girdle Muscular Dystrophy drugs based on their sale and market share.
The report also covers the Limb Girdle Muscular Dystrophy pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key Limb Girdle Muscular Dystrophy companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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Limb Girdle Muscular Dystrophy (LGMD) Therapeutics Analysis
There’s no cure for LGMD. There are supportive treatments that can help manage the symptoms of the patients. The management of limb-girdle muscular dystrophy (LGMD) is supportive; no disease-modifying treatments are available.
Treatment is aimed at the specific symptoms present in each individual. Specific treatment options may include physical and occupational therapy to improve muscle strength and prevent contractures; the use of various devices (e.g., canes, braces, walkers, wheelchairs) to assist with walking (ambulation) and mobility; surgery to correct skeletal abnormalities such as scoliosis; and regular monitoring of the heart and the respiratory system for the development of such complications potentially associated with some forms of LGMD. Genetic counseling may be of benefit to affected individuals and their families. Other treatments are symptomatic and supportive. Patients should be provided with contact details for the relevant patient organizations and registries.
Several major pharma and biotech companies are developing therapies for Limb Girdle Muscular Dystrophy. Currently, ML Bio Solutions is leading the therapeutics market with its Limb Girdle Muscular Dystrophy drug candidates in the most advanced stage of clinical development.
Limb Girdle Muscular Dystrophy (LGMD) Companies Actively Working in the Therapeutics Market Include
- ML Bio Solutions
- Asklepios BioPharmaceutical
- Sarepta Therapeutics, Inc.
- Atamyo Therapeutics
- Edgewise Therapeutics
- Vita Therapeutics
- BridgeBio Pharma
- Hansa Biopharma
And Many Others
Emerging and Marketed Limb Girdle Muscular Dystrophy (LGMD) Therapies Covered in the Report Include:
- BBP-418: ML Bio Solutions/ Bridge Bio
- AB-1003(LION-101): Asklepios Biopharmaceuticals/ Ask Bio
- SRP-9003: Sarepta Therapeutics
- ATA-100: Atamyo Therapeutics
- LGMD2B and LGMD2D: Atamyo Therapeutics
- LGMD2A: Vita Therapeutics
And Many More
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Limb Girdle Muscular Dystrophy Competitive Intelligence Analysis
4. Limb Girdle Muscular Dystrophy Market Overview at a Glance
5. Limb Girdle Muscular Dystrophy Disease Background and Overview
6. Limb Girdle Muscular Dystrophy Patient Journey
7. Limb Girdle Muscular Dystrophy Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. Limb Girdle Muscular Dystrophy Treatment Algorithm, Current Treatment, and Medical Practices
9. Limb Girdle Muscular Dystrophy Unmet Needs
10. Key Endpoints of Limb Girdle Muscular Dystrophy Treatment
11. Limb Girdle Muscular Dystrophy Marketed Therapies
12. Limb Girdle Muscular Dystrophy Emerging Drugs and Latest Therapeutic Advances
13. Limb Girdle Muscular Dystrophy Seven Major Market Analysis
14. Attribute Analysis
15. Limb Girdle Muscular Dystrophy Market Outlook (In US, EU5, and Japan)
16. Limb Girdle Muscular Dystrophy Companies Active in the Market
17. Limb Girdle Muscular Dystrophy Access and Reimbursement Overview
18. KOL Views on the Limb Girdle Muscular Dystrophy Market
19. Limb Girdle Muscular Dystrophy Market Drivers
20. Limb Girdle Muscular Dystrophy Market Barriers
21. Appendix
22. DelveInsight Capabilities
23. Disclaimer
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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About DelveInsight
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