Richter’s syndrome has a poor prognosis and the lack of FDA-approved therapies highlights a major unmet need. The emergence of novel therapies like Pirtobrutinib, P-TEFb (VIP152), Zilovertamab Vedotin, and others hold the potential to fill this gap in the Richter’s Syndrome treatment landscape.
DelveInsight’s “Richter’s Syndrome Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Richter’s Syndrome market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging Richter’s Syndrome drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Richter’s Syndrome treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Richter’s Syndrome: An Overview
Richter’s Syndrome, also known as Richter’s Transformation, is a rare complication of Chronic Lymphocytic Leukemia (CLL) and/or Small Lymphocytic Lymphoma (SLL). It is characterized by the sudden transformation of the CLL/SLL into a significantly more aggressive form of large-cell lymphoma. Two pathologic variants of RS are recognized: namely, the diffuse large B-cell lymphoma (DLBCL) variant and the rare Hodgkin lymphoma (HL) variant.
Richter’s Syndrome occurs in approximately 2-10% of all CLL/SLL patients during the course of their disease. In most cases the normally slow-growing, or indolent, CLL transforms into a common type of non-Hodgkin lymphoma (NHL) known as Diffuse Large B-cell lymphoma (DLBCL). Rarer cases transform into Hodgkin lymphoma(HL)/Hodgkin Disease (HD), and some types of T-cell lymphomas also have been reported.
The treatment for Richter’s Syndrome depends upon the exact subtype of lymphoma in question, as revealed by the diagnostic excisional or core biopsy. Chemotherapy, immunotherapy, stem cell transplant, and radiotherapy. To overcome the existing treatment challenge, companies, such as Loxo Oncology, Merck Sharp & Dohme LLC, Vincerx, and others, are developing therapies for Richter’s syndrome.
Richter’s Syndrome Market Key Facts
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According to American Cancer Society estimates, about 18,740 new cases of chronic lymphocytic leukemia (CLL) will be observed in the US in 2023.
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As mentioned by Al-Sawaf O. et al. (2021), in a German CLL Study Group (GCLLSG), a 3% prevalence of RT in a cohort of 2,975 patients with CLL longitudinally monitored after their enrolment in clinical trials was observed.
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According to Elnair Radowan et al. (2021), 74,116 patients were diagnosed with CLL between 2000 and 2016. A total of 530 patients developed RT (0.72%). Of the 530 patients who developed RT, most patients experienced transformation to a DLBCL (85%), while 81 patients (15%) developed Hodgkin lymphoma. In the same study, it was also mentioned that 62% of male and 38% of female CLL patients developed RT in the given time period.
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As per SEER, the rate of new cases of chronic lymphocytic leukemia was 4.7 per 100,000 men and women per year. In 2019, there were an estimated 200,766 people living with chronic lymphocytic leukemia in the United States.
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Richter’s Syndrome pipeline therapies. It also thoroughly assesses the Richter’s Syndrome market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete details of the market trend for each marketed Richter’s Syndrome drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Richter’s Syndrome Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted Richter’s Syndrome epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted Richter’s Syndrome epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the Richter’s Syndrome Epidemiology, Segmented as –
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Total Prevalent Cases of CLL/SLL in the 7MM [2019–2032]
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Incidence of Richters’s Syndrome in CLL/SLL in the 7MM [2019–2032]
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Diagnosed and Treatable Cases of Richters’s Syndrome in the 7MM [2019–2032]
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Variant-specific Incidence of Richters’s Syndrome in the 7MM [2019–2032] (RT-DLBCL and RT-HL)
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Mutation-specific Cases of Richter’s Syndrome in the 7MM [2019–2032]
Richter’s Syndrome Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Richter’s Syndrome market or expected to be launched during the study period. The analysis covers the Richter’s Syndrome market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the Richter’s Syndrome drugs based on their sale and market share.
The report also covers the Richter’s Syndrome pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key Richter’s Syndrome companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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Richter’s Syndrome Therapeutics Analysis
The treatment for Richter’s Syndrome depends upon the exact subtype of lymphoma in question, as revealed by the diagnostic excisional or core biopsy. In most Richter’s Syndrome cases, transformation to DLBCL is confirmed.
The current standard first-line treatment for this type of lymphoma is immuno-chemotherapy using a combination of chemodrugs and a targeted anti-CD 20 monoclonal antibody. Other second-line chemotherapy regimens often used to treat this type of lymphoma (if non-responsive or ‘refractory’ to R-CHOP) include R-ICE, D-HAC, R-DHAP, GIVE, and others. If Hodgkin lymphoma is confirmed, the current first-line is combination chemotherapy alone. Stem cell transplant using a patient’s own stem cells (autologous) or a sibling or unrelated donor (allogeneic) stem cells may also be considered in some patients if deemed clinically appropriate.
Due to the rarity of the disease, no FDA-approved therapy exists specifically for Richter’s Syndrome, and these patients are treated using regimens derived from the DLBCL treatment paradigm and other small-scale clinical trials. The prognosis of patients with Richter’s Syndrome is poor, with a median overall survival (mOS) of up to 11 months, highlighting a tremendous unmet need.
Richter’s Syndrome Companies Actively Working in the Therapeutics Market Include
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Eli Lilly and Company
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Merck Sharp & Dohme LLC
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Vincerx
And Many Others
Emerging and Marketed Richter’s Syndrome Therapies Covered in the Report Include:
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Pirtobrutinib by Loxo@Lilly, the oncology unit of Eli Lilly and Company
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Zilovertamab Vedotin (MK-2140): Merck Sharp & Dohme LLC
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Enitociclib (VIP152): Vincerx
And Many More
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Richter’s Syndrome Competitive Intelligence Analysis
4. Richter’s Syndrome Market Overview at a Glance
5. Richter’s Syndrome Disease Background and Overview
6. Richter’s Syndrome Patient Journey
7. Richter’s Syndrome Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. Richter’s Syndrome Treatment Algorithm, Current Treatment, and Medical Practices
9. Richter’s Syndrome Unmet Needs
10. Key Endpoints of Richter’s Syndrome Treatment
11. Richter’s Syndrome Marketed Therapies
12. Richter’s Syndrome Emerging Drugs and Latest Therapeutic Advances
13. Richter’s Syndrome Seven Major Market Analysis
14. Attribute Analysis
15. Richter’s Syndrome Market Outlook (In US, EU5, and Japan)
16. Richter’s Syndrome Companies Active in the Market
17. Richter’s Syndrome Access and Reimbursement Overview
18. KOL Views on the Richter’s Syndrome Market
19. Richter’s Syndrome Market Drivers
20. Richter’s Syndrome Market Barriers
21. Appendix
22. DelveInsight Capabilities
23. Disclaimer
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance.
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